Research, discovery, and evaluation are often out of reach to many founders and start-ups, yet they are often crucial for companies to show impact as they seek to grow in the marketplace. These resources are even less likely to exist for founders and companies seeking to disrupt health inequities within specific populations such as the LGBTQ+ population. Therefore, investments in early-stage start-ups with new and innovative solutions to address these health concerns are key. The Eidos LGBTQ+ Health Initiative at the University of Pennsylvania School of Nursing is partnering with Gaingels, an LGBTQIA+/Allies private investment syndicate, to provide their portfolio of companies access to Penn’s academic research to make an impact into the health and well-being of LGBTQ+ communities. Over the next five years, Gaingels portfolio companies will have the opportunity to engage with the academic, intellectual, and research resources of the University of Pennsylvania.